High energy terahertz pulses from organic crystals: DAST and DSTMS pumped at Ti:sapphire wavelength

High energy terahertz pulses are produced by optical rectification (OR) in organic crystals DAST and DSTMS by a Ti:sapphire amplifier system centered at 0.8 microns. The simple scheme provides broadband spectra between 1 and 5 THz, when pumped by collimated 60 fs near-infrared pump pulse and it is scalable in energy. Fluence-dependent conversion efficiency and damage threshold are reported as well as optimized OR at visible wavelength.Comment: 8 pages, 6 figure

Generation of 1.5-octave intense infrared pulses by nonlinear interactions in DAST crystal

Infrared pulses with large spectral width extending from 1.2 to 3.4 μ m are generated in the organic crystal DAST (4-N, N-dimethylamino-4′-N′-methylstilbazolium tosylate). The input pulse has a central wavelength of 1.5 μ m and 65 fs duration. With 2.8 mJ input energy we obtained up to 700 μ J in the broadened spectrum. The output can be easily scaled up in energy by increasing the crystal size together with the energy and the beam size of the pump. The ultra-broad spectrum is ascribed to cascaded second order processes mediated by the exceptionally large effective χ 2 nonlinearity of DAST, but the shape of the spectrum indicates that a delayed χ 3 process may also be involved. Numerical simulations reproduce the experimental results qualitatively and provide an insight in the mechanisms underlying the asymmetric spectral broadening

Neuropharmacological Modulation of N-methyl-D-aspartate, Noradrenaline and Endocannabinoid Receptors in Fear Extinction Learning: Synaptic Transmission and Plasticity

Learning to recognize and respond to potential threats is crucial for survival. Pavlovian threat conditioning represents a key paradigm for investigating the neurobiological mechanisms of fear learning. In this review, we address the role of specific neuropharmacological adjuvants that act on neurochemical synaptic transmission, as well as on brain plasticity processes implicated in fear memory. We focus on novel neuropharmacological manipulations targeting glutamatergic, noradrenergic, and endocannabinoid systems, and address how the modulation of these neurobiological systems affects fear extinction learning in humans. We show that the administration of N-methyl-D-aspartate (NMDA) agonists and modulation of the endocannabinoid system by fatty acid amide hydrolase (FAAH) inhibition can boost extinction learning through the stabilization and regulation of the receptor concentration. On the other hand, elevated noradrenaline levels dynamically modulate fear learning, hindering long-term extinction processes. These pharmacological interventions could provide novel targeted treatments and prevention strategies for fear-based and anxiety-related disorders

Flood impacts on a water distribution network

Floods cause damage to people, buildings and infrastructures. Water distribution systems are particularly exposed, since water treatment plants are often located next to the rivers. Failure of the system leads to both direct losses, for instance damage to equipment and pipework contamination, and indirect impact, since it may lead to service disruption and thus affect populations far from the event through the functional dependencies of the network. In this work, we present an analysis of direct and indirect damages on a drinking water supply system, considering the hazard of riverine flooding as well as the exposure and vulnerability of active system components. The method is based on interweaving, through a semi-automated GIS procedure, a flood model and an EPANET-based pipe network model with a pressure-driven demand approach, which is needed when modelling water distribution networks in highly off-design conditions. Impact measures are defined and estimated so as to quantify service outage and potential pipe contamination. The method is applied to the water supply system of the city of Florence, Italy, serving approximately 380 000 inhabitants. The evaluation of flood impact on the water distribution network is carried out for different events with assigned recurrence intervals. Vulnerable elements exposed to the flood are identified and analysed in order to estimate their residual functionality and to simulate failure scenarios. Results show that in the worst failure scenario (no residual functionality of the lifting station and a 500-year flood), 420 km of pipework would require disinfection with an estimated cost of EUR 21 million, which is about 0.5 % of the direct flood losses evaluated for buildings and contents. Moreover, if flood impacts on the water distribution network are considered, the population affected by the flood is up to 3 times the population directly flooded

Desain Sistem Pipa Distribusi Gas untuk Sektor Perumahan dan Komersial di Wilayah Kebayoran Baru – Jakarta Selatan

Pemanfaatan gas alam di Indonesia untuk sektor Perumahan dan komersial masih belum optimum, termasuk di wilayah ibukota. Berbagai kebijakan telah dirumuskan pemerintah untuk mendukung pemanfaatan gas alam termasuk meningkatkan infrastruktur penyaluran gas alam. Tujuan utama dari studi ini adalah untuk melakukan perancangan sistem pipa distribusi gas untuk sektor Perumahan dan komersial di wilayah Kebayoran Baru (Jakarta Selatan) serta melakukan analisa kelayakan ekonomi dari proyek tersebut. Kebayoran Baru adalah wilayah yang potensial untuk dilakukan pengembangan gas kota. Berdasarkan perhitungan yang telah dilakukan di studi ini, kebutuhan gas untuk sektor Perumahan dan komersial di Kebayoran Baru adalah sekitar 0,9 MMSCFD. Studi ini mencakup pula pemilihan rute untuk sistem pipa distribusi gas di wilayah tersebut. Berdasarkan hasil simulasi dengan perangkat lunak Fluid Flow dan dikonversi dengan spesifikasi pipa komersial yang ada di pasaran, diameter pipa yang akan digunakan adalah 180 mm, 90 mm, dan 63 mm. Total panjang pipa distribusi tersebut adalah 20,3 m. Dari hasil studi ini, rancangan tersebut akan layak dari segi ekonomi apabila harga jual gas sebesar Rp3.141/m3dan harga ini lebih rendah dibandingkan harga LPG untuk wilayah Jakarta